Quinolines and derivatives

Aromatic organic heterocyclic compounds that contain a benzene ring fused with a six-membered ring that contains one nitrogen atom and five carbon atoms. Includes compounds that are derived from quinolines.

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2,266 – 2,280 of 3,759 results

2,266

Apexbio Technology LLC JNJ-26481585 875320-29-9 200mg

JNJ-26481585 (CAS 875320-29-9) is a small-molecule inhibitor targeting class I histone deacetylases (HDACs) specifically HDAC1 HDAC2 and HDAC3 with reported IC50 values of 0 11 0 33 and 4 8 nM respectively It exhibits potent anti-proliferative activity across various human cancer cell lines including lung breast colon prostate ovarian and brain cancers (IC50 range 3 1 246 nM) Mechanistically JNJ-26481585 induces histone H3 acetylation alleviates HDAC-mediated repression of the p21waf1 cip1 promoter and promotes apoptosis in colorectal cancer cell models Consequently this compound serves as a research tool for cancer epigenetics and therapeutic assessment

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2,267

eMolecules tert-Butyl 4-bromo-2,6-difluorobenzoate | 955887-09-9 | MFCD08703422 | 1g

Ambeed | tert-Butyl 4-bromo-2,6-difluorobenzoate | 1g | 525233426 | A684468 | | 955887-09-9 | MFCD08703422 | 293.108 | C11H11BrF2O2

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2,268

Medchemexpress LLC Isavuconazole | 241479-67-4 | 99.9% | C22H17F2N5OS | 200 MG

Isavuconazole is a triazole proagent that exhibits antifungal activity against yeasts, molds, and dimorphic fungi. It functions by inhibiting ergosterol biosynthesis, which leads to the disruption of the fungal membrane structure and function. Isavuconazole is also identified as a moderate inhibitor of CYP3A4.

Triazole proagent
Exhibits antifungal activity against yeasts, molds, and dimorphic fungi
Inhibits ergosterol biosynthesis
Disrupts fungal membrane structure and function
Moderate inhibitor of CYP3A4

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2,269

Medchemexpress LLC Revumenib | 2169919-21-3 | 99.99% | 630.82 | 200 MG

Revumenib (SNDX-5613) is a potent and specific Menin-MLL inhibitor with a binding Ki of 0.149 nM and a cell-based IC50 of 10-20 nM. It is intended for the research of MLL-rearranged (MLL-r) acute leukemias, including acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). For research use only; not for sale to patients.

Potent and specific Menin-MLL inhibitor.
Applicable for research in MLL-rearranged acute leukemias (ALL and AML).
Shows in vivo plasma IC50 of 53 nM.
Provides significant survival benefit and leukemic control in aggressive MOLM-13 disseminated xenografts in vivo.

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2,270

Ambeed Benzyl 3oxocyclobutyl carbama

Benzyl (3-oxocyclobutyl)carbamate, 130369-36-7, 97%

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2,271

Medchemexpress LLC 3,6,9,12,15,18-Hexaoxaeicosane-1,20-diamine | 76927-70-3 | ≥97.0% | 324.41 | 1 G

Amino-PEG6-amine is a PEG-based (6 units) PROTAC linker that can be utilized in the synthesis of PROTACs. It is intended for research use only.

PEG-based (6 units) PROTAC linker
Can be used in the synthesis of PROTACs

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2,272

Medchemexpress LLC Amino-PEG6-amine | 76927-70-3 | ≥ 97.0% | 324.41 | 100 MG

Amino-PEG6-amine is a PEG-based (6 units) PROTAC linker. It can be used in the synthesis of PROTACs, which are molecules that exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. PROTACs achieve this by containing two different ligands connected by a linker: one ligand binds to an E3 ubiquitin ligase, and the other binds to the target protein.

PEG-based PROTAC linker
Used in the synthesis of PROTACs
Exploits the ubiquitin-proteasome system
Selectively degrades target proteins

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2,273

Medchemexpress LLC Argatroban (monohydrate) | 141396-28-3 | 99.6% | 5 MG

Argatroban (monohydrate) is a direct, selective thrombin inhibitor used for research purposes. It is effective in preventing thrombus formation and has been studied for its use in creating animal models for thrombolysis.

Suitable for high-speed applications
Available in solid form
Used to inhibit thrombin activity in animals
Has potential for preventing thrombus formation without aggravating bleeding
Can enhance reperfusion with TPA in patients with AMI

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2,274

Medchemexpress LLC Phentolamine mesylate | 65-28-1 | 99.9% | 500 MG

Phentolamine mesylate is a reversible, non-selective, and orally active blocker of α1 and α2 adrenergic receptors. It expands blood vessels to reduce peripheral vascular resistance and can be used for the research of pheochromocytoma-related hypertension, heart failure, and erectile dysfunction.

Reversible, non-selective, and orally active blocker of α1 and α2 adrenergic receptors
Expands blood vessels to reduce peripheral vascular resistance
Used for research in pheochromocytoma-related hypertension, heart failure, and erectile dysfunction
High purity of 99.9%

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2,275

Medchemexpress LLC Bromocriptine mesylate | 22260-51-1 | 99.90% | 200 MG

Bromocriptine mesylate is a potent dopamine D2/D3 receptor agonist, binding to the D2 dopamine receptor with a pKi of 8.05. It is permeable to the blood-brain barrier. This compound also acts as a strong inhibitor of brain nitric oxide synthase (NOS) with an IC50 of 10±2 μM for purified neuronal NOS, and poorly inhibits inducible macrophage NOS (IC50>100 μM). Additionally, it is a potent inhibitor of CYP3A4, with a calculated IC50 value of 1.69 μM.

Potent dopamine D2/D3 receptor agonist
Permeable to the blood-brain barrier
Strong inhibitor of brain nitric oxide synthase (NOS)
Potent inhibitor of CYP3A4
Shows anti-immobility action in mice (in FST and TST)
Potentiates the anti-immobility action of MPE
Decreases static mechanical allodynia (SMA) score in rats

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2,276

Medchemexpress LLC DOTMA | 104872-42-6 | 99.91% | 670.57 | 200 MG

DOTMA is a cationic lipid used as a non-viral vector for gene therapy. It is a component of liposomes for encapsulating siRNA, microRNA, and oligonucleotides, and for in vitro gene transfection. DOTMA promotes effective interaction between liposomes and cell membranes by inducing positive charge on the liposomes. It has demonstrated good gene transfection effects both in vitro and in vivo.

Cationic lipid
Non-viral vector for gene therapy
Component of liposomes for encapsulating siRNA, microRNA, and oligonucleotides
Used for in vitro gene transfection
Promotes effective interaction between liposomes and cell membranes
Induces positive charge on liposomes
Good gene transfection effects both in vitro and in vivo
High intravenous transfection activity in CD-1 mouse

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2,277

Apexbio Technology LLC PF-543 1415562-82-1 200mg

PF-543 (CAS 1415562-82-1) is a cell-permeable inhibitor targeting sphingosine kinase 1 (SphK1) an enzyme that phosphorylates sphingosine to sphingosine-1-phosphate (S1P) It displays potent inhibitory activity against SphK1 with an IC50 of 3 6 nM through sphingosine-competitive (non-ATP competitive) binding Treatment of SphK1-overexpressing head and neck cancer (1483) cells led to a ten-fold decrease in S1P levels confirming effective target engagement PF-543 is widely utilized as a research tool in studies investigating SphK1-mediated signaling pathways in cancer biology and immune cell trafficking

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2,278

Medchemexpress LLC Dactolisib | 915019-65-7 | >99% | C30H23N5O | 200 MG

Dactolisib (BEZ235) is an orally active, dual pan-class I PI3K, and mTOR kinase inhibitor. It inhibits both mTORC1 and mTORC2, demonstrating potent activity against PI3K in an ATP competitive manner. This compound is known to reduce phosphorylation levels of mTOR activated kinase p70S6K and S235/S236P-RPS6.

Dual pan-class I PI3K and mTOR kinase inhibitor
Orally active
Inhibits both mTORC1 and mTORC2
Potently inhibits PI3K in an ATP competitive manner
Effective in reducing phosphorylation levels of p70S6K and S235/S236P-RPS6

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2,279

Medchemexpress LLC Iox1 10Mm 1Ml In Dmso | HY-12304

Iox1 10Mm 1Ml In Dmso

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2,280

Medchemexpress LLC NP118809 | 41332-24-5 | 98.73% | C₃₂H₃₂N₂O | 200 MG

NP118809 is a potent N-type calcium channel blocker with an IC₅₀ of 0.11 μM, and also inhibits L-type calcium channels less potently with an IC₅₀ of 12.2 μM. It is intended for research use only.

Potent N-type calcium channel blocker (IC₅₀ of 0.11 μM).
Inhibits L-type calcium channels (IC₅₀ of 12.2 μM).
Shows significant analgesic activity in the phase IIA portions of the rat formalin model (25 mg/kg, i.p.).
Results in 80.3% inhibition of mechanical allodynia and 96.3% inhibition of thermal hyperalgesia in the rat spinal nerve ligation model (30 mg/kg, p.o.).
Available in solid form, light yellow to yellow in color.

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Quinolines and derivatives

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Apexbio Technology LLC JNJ-26481585 875320-29-9 200mg Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Isavuconazole | 241479-67-4 | 99.9% | C22H17F2N5OS | 200 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Revumenib | 2169919-21-3 | 99.99% | 630.82 | 200 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC 3,6,9,12,15,18-Hexaoxaeicosane-1,20-diamine | 76927-70-3 | ≥97.0% | 324.41 | 1 G Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Amino-PEG6-amine | 76927-70-3 | ≥ 97.0% | 324.41 | 100 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Argatroban (monohydrate) | 141396-28-3 | 99.6% | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Phentolamine mesylate | 65-28-1 | 99.9% | 500 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Bromocriptine mesylate | 22260-51-1 | 99.90% | 200 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC DOTMA | 104872-42-6 | 99.91% | 670.57 | 200 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Apexbio Technology LLC PF-543 1415562-82-1 200mg Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Dactolisib | 915019-65-7 | >99% | C30H23N5O | 200 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Iox1 10Mm 1Ml In Dmso | HY-12304 Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC NP118809 | 41332-24-5 | 98.73% | C₃₂H₃₂N₂O | 200 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More